Older men’s growth factor 1 blood tests
What Sermorelin changed in growth factor 1 tests
Growth factor 1 rose in older men. See why a growth factor 1 result isn’t the same as better health.
What the liver blood test tells you
Less strength or poor sleep may get your notice before your blood test does. Growth factor 1 is a hormone your liver makes after growth hormone reaches it.
Sermorelin doesn’t contain growth factor 1. It prompts the small gland below your brain to send growth hormone first, and growth factor 1 may rise later.
In healthy older men, higher study amounts led to larger rises in growth hormone and growth factor 1 [2]. A related drug also raised growth factor 1 in men with low testosterone [7].
I’d want the limit of a growth factor 1 test stated clearly. A growth factor 1 rise doesn’t prove you’ll sleep better, that your strength will improve, or that you’ll live longer.
Your own blood result needs your doctor’s full view. You can’t read health from one hormone.
What Sermorelin changed in growth factor 1
Researchers compared 10 healthy older men with 9 young men. The older men had an average age of 68.
For fourteen days, the older men got under-the-skin shots of 0.5 mg and 1 mg twice daily [2]. Their 24-hour growth hormone and growth factor 1 rose more after the larger amount.
At 1 mg, the growth hormone and growth factor 1 results were close enough that the test couldn’t tell them apart from the young men’s results [2]. That doesn’t mean the older men became as healthy as the young men.
The fasting sugar test didn’t change. The study lasted only two weeks and didn’t test longer life.
Both growth hormone and growth factor 1 often fall as you age. Sermorelin moved those blood numbers toward the young men’s numbers, but daily health wasn’t measured.
What Sermorelin may do to growth factor 1
Healthy older men got 0.5-1 mg twice daily for 14 days. Their 24-hour growth hormone and growth factor 1 rose, and the higher amount brought results like those of young men [2].
Their livers made growth factor 1 after growth hormone rose. That growth factor 1 rise came from a two-week study, which can’t tell you what long use would do.
What studies found about Sermorelin and testosterone
Sermorelin works through growth hormone, not the glands that make testosterone. Even so, the two hormone systems can affect each other.
Healthy men aged 60-77 got testosterone. Both their low steady flow and their short bursts of growth hormone rose, along with growth factor 1.
Testosterone didn’t make their gland release more growth hormone when either of two test drugs was given [10]. In another study, deep belly fat explained 41% of the difference between men, and growth factor 1 helped forecast the gland’s reply [9].
A second study gave lab-made growth factor 1 to middle-aged and older men. With more testosterone, high growth factor 1 was less able to slow growth hormone release [11].
This is the useful part for you. Testosterone can change these growth factor 1 and growth hormone tests, but no study here shows Sermorelin raises testosterone.
What Sermorelin hasn’t shown about testosterone
Sermorelin acts through growth hormone and growth factor 1, not the glands that make testosterone. In healthy older men, testosterone raised both hormones and changed how your growth gland replied to a brain hormone [10].
Growth factor 1 and testosterone can affect one another. Still, studies haven’t shown Sermorelin raising testosterone; they tested testosterone’s effect on growth hormone.
What Sermorelin studies don’t tell you about taking both
This page reports study results, not a plan for mixing drugs. In older men, testosterone made high growth factor 1 less able to slow growth hormone release [11].
Studies haven’t shown that taking both drugs on your own is safe. They tracked growth factor 1 and other short-term blood tests, not how men felt or what years of growth factor 1 changes might do.
What happened to growth factor 1 in men with low testosterone
Men with low testosterone received a drug that prompts growth hormone release. Their growth factor 1 blood test rose [7].
A review asked whether drugs like that might change fat and muscle [8]. It found a blood-test change, not proof of more muscle or less fat.
That difference matters for your goal. Tests of Sermorelin itself are still scarce.
A 2025 review described where doctors are still testing related drugs [12]. It didn’t prove a daily benefit from a higher growth factor 1 result.
A growth factor 1 number can move while you feel no better. One small study can’t answer what the drug would do for you.